Measurement of blood-brain barrier permeability with positron emission tomography and [68Ga]EDTA
Creators
- 1. Department of Nuclear Medicine, National Institute on Aging, Bethesda, Maryland
Description
Positron emission tomography (PET) was employed to examine time-dependent changes in blood-brain barrier (BBB) permeability to [68Ga]ethylenediaminetetraacetate (EDTA) in the rhesus monkey, following reversible barrier opening by intracarotid infusion of a hypertonic mannitol solution. The PET technique, when combined with measurements of plasma radioactivity, provided a quantitative measure of the cerebrovascular permeability-area product (PA) at different times following mannitol infusion. Hypertonic mannitol treatment reversibly increased PA to [68Ga]EDTA more than 10-fold; much of the barrier effect was over by 10 min after mannitol treatment. The results show that PET can be used to measure transient changes in BBB integrity in specific brain regions, under in vivo, noninvasive conditions
Additional details
Publishing Information
- Journal Title
- J. Cereb. Blood Flow Metab.
- Journal Volume
- 4
- Journal Issue
- 3
- Series
- J. Cereb. Blood Flow Metab.
- Journal Page Range
- 323-328
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 16045773
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD-BRAIN BARRIER; BRAIN; EDTA; GALLIUM 68; MACACUS; PERMEABILITY; POSITRON COMPUTED TOMOGRAPHY
- Descriptors DEC
- AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; CHELATING AGENTS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; GALLIUM ISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; MONKEYS; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RADIOISOTOPES; TOMOGRAPHY; VERTEBRATES