Exploration by radioactive fibrinogen of intrarenal coagulation phenomena. Preliminary results
Description
The participation of fibrin deposits in kidney pathology was studied by the use of a radioactive tracer involved in the coagulation phenomenon: iodine 131-labelled fibrinogen. The isotopic exploration consists of a fibrinogen kinetics study combined with external counting over the kidney regions. The different stages of the procedure are described: separation, purification and labelling of fibrinogen; characteristics of the radioactive fibrinogen used; practical details of the examination itself; data analysis method. A chapter devoted to verifications and discussions of the procedure is followed by a report on the exploration of intrarenal coagulation phenomena in 30 kidney disease patients. In conclusion, the study of fibrinogen kinetics is considered as the most suitable method to detect local or slight intravascular coagulation phenomena. The sensitivity of the isotopic exploration is very satisfactory. The main criticism directed against this method is that the exploration is general and therefore blind
Availability note (English)
MF available from INIS under the Report Number.Abstract (French)
La participation des depots de fibrine en pathologie renale a ete etudiee a l'aide d'un traceur radioactif intervenant dans le phenomene de coagulation: le fibrinogene marque a l'iode 131. L'exploration isotopique consiste en une etude de la cinetique du fibrinogene, completee par des comptages externes sur les aires renales. Les differentes phases de la methodologie sont decrites: isolement, purification et marquage du fibrinogene; caracteres du fibrinogene radioactif utilise; realisation pratique de l'exploration, methode d'exploitation des donnees experimentales. Apres un chapitre consacre aux verifications et discussions de cette methodologie on presente un travail relatif a l'exploration des phenomenes de coagulation intrarenale chez 30 patients atteints de nephropathies. En conclusion, l'etude de la cinetique du fibrinogene est consideree comme la methode la plus appropriee a la detection des phenomenes de coagulation intravasculaire localisee ou de faible importance. La sensibilite de l'exploration isotopique est tres satisfaisante. Le principal reproche formule a l'encontre de cette methode est qu'il s'agit d'une exploration aveugle car globaleFiles
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Additional details
Additional titles
- Original title (French)
- Exploration par le fibrinogene radioactif des phenomenes de coagulation intra-renale. Resultats preliminaires
Publishing Information
- Imprint Pagination
- 72 p.
- Report number
- FRNC-TH--712
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 11508524
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Thesis
- Descriptors DEI
- BLOOD COAGULATION; FIBRINOGEN; IODINE 131; KIDNEYS; TRACER TECHNIQUES
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD COAGULATION FACTORS; BODY; DAYS LIVING RADIOISOTOPES; GLOBULINS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES