Published April 1992
| Version v1
Journal article
Radiosensitization efficacy of KU-2285, RP-170 and etanidazole at low radiation doses: assessment by in vitro cytokinesis-block micronucleus assay
- 1. Essen Univ. (Gesamthochschule) (Germany)
- 2. Kyoto Univ. (Japan). Faculty of Medicine
Description
Since the cytokinesis-block micronucleus assay is very sensitive at low radiation doses, the authors used it to investigate the in vitro sensitizing effects of two new hypoxic cell sensitizers (KU-2285, a fluorinated 2-nitroimidazole and RP-170, a 2-nitroimidazole nucleoside analogue) at 1-3 Gy in comparison with etanidazole. When the cells were pretreated under aerobic conditions, KU-2285 and RP-170 had a sensitizing effect whereas etanidazole did not. Results suggest the potential usefulness of KU-2285 and RP-170 in clinical radiotherapy. (author)
Additional details
Publishing Information
- Journal Title
- International Journal of Radiation Biology
- Journal Volume
- 61
- Journal Issue
- 4
- Series
- Int. J. Radiat. Biol.
- Journal Page Range
- 473-478
- ISSN
- 0955-3002
- CODEN
- IJRBE
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 23057924
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANOXIA; BIOASSAY; BIOLOGICAL INDICATORS; CELL NUCLEI; COMPARATIVE EVALUATIONS; IMIDAZOLES; LOW DOSE IRRADIATION; RADIOSENSITIVITY; RADIOSENSITIZERS; TEMPERATURE RANGE 0273-0400 K
- Descriptors DEC
- AZOLES; CELL CONSTITUENTS; DRUGS; EVALUATION; HETEROCYCLIC COMPOUNDS; IRRADIATION; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PERFORMANCE TESTING; RESPONSE MODIFYING FACTORS; TEMPERATURE RANGE; TESTING