Influence of electrospun scaffolds prepared from distinct polymers on proliferation and viability of endothelial cells
Creators
- 1. Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 (Russian Federation)
Description
We compared electrospun nonwoven scaffolds from polylactic acid (PLA), polycaprolactone (PCL), and polyhydroxybutyrate/valerate (PHBV)/polycaprolactone (PHBV/PCL). The surface of PHBV/PCL and PCL scaffolds was highly porous and consisted of randomly distributed fibers, whilst the surface of PLA scaffolds consisted of thin straight fibers, which located more sparsely, forming large pores. Culture of EA.hy 926 endothelial cells on these scaffolds during 7 days and further fluorescent microscopy demonstrated that the surface of PHBV/PCL scaffolds was most favorable for efficient adhesion, proliferation, and viability of endothelial cells. The lowest proliferation rate and cell viability were detected on PLA scaffolds. Therefore, PHBV/PCL electrospun nonwoven scaffolds demonstrated the best results regarding endothelial cell proliferation and viability as compared to PCL and PLA scaffolds
Additional details
Identifiers
- DOI
- 10.1063/1.4932834;
Publishing Information
- Journal Title
- AIP Conference Proceedings
- Journal Volume
- 1683
- Journal Issue
- 1
- Journal Page Range
- p. 020144-020144.4
- ISSN
- 0094-243X
- CODEN
- APCPCS
Conference
- Title
- International conference on advanced materials with hierarchical structure for new technologies and reliable structures 2015
- Dates
- 21-25 Sep 2015
- Place
- Tomsk (Russian Federation)
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 47062701
- Subject category
- S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ADHESION; CELL PROLIFERATION; COMPARATIVE EVALUATIONS; FIBERS; FLUORESCENCE; LACTONES; MICROSCOPY; POLYMERS; POROUS MATERIALS; RANDOMNESS; SURFACES; VIABILITY
- Descriptors DEC
- EMISSION; ESTERS; EVALUATION; HETEROCYCLIC COMPOUNDS; LUMINESCENCE; MATERIALS; ORGANIC COMPOUNDS; PHOTON EMISSION
Optional Information
- Notes
- (c) 2015 AIP Publishing LLC