Effectiveness of Combined Treatment with Vitamin C and Cystamine in Controlling Blood Hyperlipemia in Irradiated Rats
Creators
- 1. National Center for Radiation Research and Technology, A.E.A., Cairo, (Egypt)
Description
The present work was directed to evaluate the effectiveness of treatment with vitamin C and/ or cystamine, 24 hours post- irradiation exposure (6.5 Gy), in controlling post- irradiation hyperlipemia in blood of irradiated rats through estimation of blood lipid fractions (total lipids, triglycerides, phospholipids). Data obtained in this study revealed that whole body gamma-irradiation (6.5 Gy) induced significant elevation in all tested blood lipid fractions. Intraperitoneal treatment of gamma- irradiated rats tripple doses of vitamin C (100 mg/kg) in combination with cystamine (50 mg/kg) for 24 hours at 8 hours intervals, was found to be more effective in controlling radiation induced elevation in all tested blood lipid fractions than with single treatment with either of the two materials
Additional details
Publishing Information
- Journal Title
- Isotope and Radiation Research
- Journal Volume
- 28
- Journal Issue
- 1,2
- Journal Page Range
- p. 43-48
- ISSN
- 0021-1907
INIS
- Country of Publication
- Egypt
- Country of Input or Organization
- Egypt
- INIS RN
- 31000419
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CHOLESTEROL; CYSTAMINE; GAMMA RADIATION; IRRADIATION; LIPIDS; PHOSPHOLIPIDS; RATS; TRIGLYCERIDES
- Descriptors DEC
- AMINES; ANIMALS; DRUGS; ELECTROMAGNETIC RADIATION; ESTERS; HYDROXY COMPOUNDS; IONIZING RADIATIONS; LIPIDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; STEROIDS; STEROLS; VERTEBRATES
Optional Information
- Notes
- 1 tab.