Synthesis of Novel Isochromen-1-one analogues of Etodolac

In the present work, anti-inflammatory drug based novel isochromen-1-one, their thio and N-methylated analogues were synthesized from the etodolac bulk drug, 1. All the synthesized compounds were purified and successfully characterized by FT-IR, ¹H NMR, ¹³C NMR and Mass spectroscopy. All the derivatives procured are with remarkable yields from 67-72%. (paper)