Published August 1995 | Version v1
Journal article Metadata-only

Preparation of bone tumor therapeutic radiopharmaceuticals 153Sm-EDTMP

Creators

  • 1. China Academy of Engineering Physics, Chengdu, SC (China). Inst. of Nuclear Physics and Chemistry

Description

Samarium-153-EDTMP (ethylene diamine tetramethylene phosphonate), for its promising biological properties, has been proved as a palliating therapeutic agent for bone tumor in human beings. 153Sm with high radionuclear purity and specific activity of 5.18 GBq (140 mCi)/mg Sm2O3 was prepared by irradiating natural Sm2O3(152Sm, 26.7%) sample, replacing costly enriched samarium oxide target, at a flux of 4 x 1013 n·cm-2·s-1 for 110 h. The yield of 153Sm complexing with EDTMP is greater than 98% at pH 8∼10 in boiling water bath for 30 min, and not significantly decreases within one week after 153Sm-EDTMP complex formation

Additional details

Publishing Information

Journal Title
Nuclear Science and Techniques
Journal Volume
6
Journal Issue
3
Journal Page Range
p. 146-149.
ISSN
1001-8042
CODEN
NSETEC

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
27004288
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ANTINEOPLASTIC DRUGS; CHEMICAL PREPARATION; LABELLING; NEOPLASMS; NEUTRON BEAMS; NEUTRON REACTIONS; PH VALUE; PHOSPHONIC ACID ESTERS; RADIOPHARMACEUTICALS; SAMARIUM COMPLEXES; SAMARIUM OXIDES; SAMARIUM 152 TARGET; SAMARIUM 153; SKELETAL DISEASES; STABILITY; THERAPY
Descriptors DEC
BARYON REACTIONS; BEAMS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHALCOGENIDES; COMPLEXES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ESTERS; EVEN-ODD NUCLEI; HADRON REACTIONS; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MEDICINE; NUCLEAR REACTIONS; NUCLEI; NUCLEON BEAMS; NUCLEON REACTIONS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; PARTICLE BEAMS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RARE EARTH COMPLEXES; RARE EARTH COMPOUNDS; RARE EARTH NUCLEI; SAMARIUM COMPOUNDS; SAMARIUM ISOTOPES; SYNTHESIS; TARGETS