Published June 2018 | Version v1
Journal article Metadata-only

[18F]-GE-179 positron emission tomography (PET) tracer for N-methyl-d-aspartate receptors: One-pot synthesis and preliminary micro-PET study in a rat model of MCAO

Creators

  • 1. PET Center, Huashan Hospital, Fudan University, No. 518, East Wuzhong Road, Xuhui District, Shanghai 200235 (China)
  • 2. Institute of Integrative Medicine, Fudan University, No. 12, Middle Urumqi Road, Jing'an District, Shanghai 200040 (China)

Description

The objective of this study was to synthesize an N-methyl-d-aspartate receptor (NMDAR) radiotracer [18F]-GE-179 in one-pot and evaluate its in vivo binding for NMDAR activation after brain ischemia reperfusion injury.

Additional details

Identifiers

DOI
10.1016/j.nucmedbio.2018.04.002;
PII
S0969805117302895;

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
61
Journal Page Range
p. 45-55
ISSN
0969-8051
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
55042932
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
BRAIN; CEREBRAL ARTERIES; FLUORINE 18; IN VIVO; INJURIES; ISCHEMIA; POSITRON COMPUTED TOMOGRAPHY; RATS; RECEPTORS; SYNTHESIS; TRACER TECHNIQUES
Descriptors DEC
ANEMIAS; ANIMALS; ARTERIES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEMIC DISEASES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MEMBRANE PROTEINS; NANOSECONDS LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; RODENTS; SYMPTOMS; TOMOGRAPHY; VASCULAR DISEASES; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2018 Elsevier Inc. All rights reserved.