Published 1999 | Version v1
Miscellaneous Metadata-only

115m In utilization in Diethylenetriamine Pentaacetic acid (DTPA) labelling

Creators

  • 1. Minas Gerais Univ., Belo Horizonte, MG (Brazil). Dept. de Quimica
  • 2. Minas Gerais Univ., Belo Horizonte, MG (Brazil). Faculdade de Farmacia. Setor de Radioquimica

Description

The purpose of this study is to determine ideal conditions for the preparation of 115m In-Diethylenetriamine Pentaacetic Acid. This labelled compound would be useful in studies of renal function and in the diagnose of tissue rejection by patients submitted to renal transplants. The 115m In-DTPA was injected i.v. mouse weighting about 25 g to investigate its biological distribution. The results showed that few minutes after administration high uptake radiation was found in kidneys when compared with other organs. High levels were also found in bladder. These data together with radiochemical purity, sterility, and apyrogenic studies recommend this radiopharmaceuticals for application in scintilographic studies of patients with renal disorders. (author)

Availability note (English)

Available from the library of the Brazilian Nuclear Energy Commission, Rio de Janeiro

Additional details

Additional titles

Original title (Portuguese)
Utilizacao do

Publishing Information

Imprint Pagination
3 p.

Conference

Title
7. General congress on nuclear energy
Original Conference Title
7. Congresso geral de energia nuclear
Dates
31 Aug - 3 Sep 1999
Place
Belo Horizonte, MG (Brazil)

INIS

Country of Publication
Brazil
Country of Input or Organization
Brazil
INIS RN
30041669
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
DTPA; INDIUM 115; KIDNEYS; LABELLED COMPOUNDS; LABELLING; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RATS; SCINTISCANNING; UPTAKE
Descriptors DEC
AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CHELATING AGENTS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; HOURS LIVING RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
7 ref., 1 fig., 1 tab.