Published 1985
| Version v1
Book
Radiolysis of DNA and model systems in the presence of oxygen
- 1. Max-Planck-Institut fuer Kohlenforschung, Muelheim an der Ruhr (Germany, F.R.). Inst. fuer Strahlenchemie
Description
In relation to radiation damage of DNA, a summary is given of the current knowledge of the decay of peroxyl radicals of DNA and model systems such as free bases or sugar phosphates in aqueous solutions. The discussion is restricted to peroxyl radicals formed by the reaction of OH radicals and solvated electrons with DNA and model systems. The mechanisms and biological consequences of radiation-induced strand breaks in DNA and polynucleotides are discussed. New developments in the understanding of the 'oxygen effect', i.e. the increased sensitivity of cells to radiation in the presence of oxygen, are described. (U.K.)
Additional details
Publishing Information
- Publisher
- Academic Press.
- Imprint Place
- London (UK)
- ISBN
- 0-12-642760-7
- Imprint Title
- Oxidative stress
- Imprint Pagination
- 522 p.
- Journal Page Range
- p. 11-40.
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 17039320
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- DNA; HYDROPEROXY RADICALS; HYDROXYL RADICALS; NUCLEOSIDES; NUCLEOTIDES; OXYGEN; PEROXY RADICALS; PURINES; PYRIMIDINES; RADIOLYSIS; RESPONSE MODIFYING FACTORS; STRAND BREAKS
- Descriptors DEC
- AZINES; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; DECOMPOSITION; ELEMENTS; HETEROCYCLIC COMPOUNDS; NONMETALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIATION EFFECTS; RADICALS; RIBOSIDES