Published August 15, 2019 | Version v1
Journal article Metadata-only

Early therapeutic effects of adaptive servo-ventilation on cardiac sympathetic nervous function in patients with heart failure evaluated using a combination of 11C-HED PET and 123I-MIBG SPECT

Creators

  • 1. Hokkaido University Graduate School of Medicine, Department of Cardiovascular Medicine (Japan)
  • 2. Tokyo Tenshi Hospital, Department of Cardiovascular Medicine (Japan)
  • 3. National Institute of Radiological Sciences, Diagnostic and Therapeutic Nuclear Medicine (Japan)
  • 4. Otaru Kyokai Hospital, Department of Cardiovascular Medicine (Japan)
  • 5. Hakodate Neurosurgery Hospital, Department of Cardiovascular Medicine (Japan)
  • 6. Hokkaido University Graduate School of Medicine, Department of Nuclear Medicine (Japan)
  • 7. Kyushu University, Department of Cardiovascular Medicine, Graduate School of Medical Sciences (Japan)

Description

Rationale

Adaptive servo-ventilation (ASV), a novel respiratory support therapy for sleep disorders, may improve cardiac function in heart failure (HF). However, the reasons that ASV improves cardiac function have not been fully studied especially in sympathetic nervous function (SNF). The purpose of the present study was to investigate the effects of ASV therapy on cardiac SNF in patients with HF.

Methods

We evaluated ASV therapeutic effects before and 6 months after ASV therapy in 9 HF patients [57.3 ± 17.3 years old, left ventricular ejection fraction (LVEF) 36.1 ± 16.7%]. We performed echocardiography, polysomnography, biomarkers, 11C-hydroxyephedrine (HED) PET as a presynaptic function marker and planar 123I-metaiodobenzylguanidine (MIBG) to evaluate washout rate.

Results

ASV therapy reduced apnea-hypopnea index (AHI) and improved plasma brain natriuretic peptide (BNP) concentration. In 123I-MIBG imaging, the early heart/mediastinum (H/M) ratio increased after ASV therapy (2.19 ± 0.58 to 2.40 ± 0.67; P = 0.045). Washout rate did not change (23.8 ± 7.3% to 23.8 ± 8.8%; P = 0.122). Global 11C-HED retention index (RI) improved from 0.068 ± 0.033/s to 0.075 ± 0.034/s (P = 0.029).

Conclusions

ASV reduced AHI and improved BNP. ASV might initially improve presynaptic cardiac sympathetic nervous function in HF patients after 6 months of treatment.

Additional details

Identifiers

DOI
10.1007/s12350-017-1132-4;

Publishing Information

Journal Title
Journal of Nuclear Cardiology (Online)
Journal Volume
26
Journal Issue
4
Journal Page Range
p. 1079-1089
ISSN
1532-6551

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
52001968
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL MARKERS; BRAIN; CARBON 11; HEART; IODINE 123; MEDIASTINUM; MIBG; POSITRON COMPUTED TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; THERAPY
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CARBONIC ACID DERIVATIVES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; CHEST; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; GUANIDINES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LIGHT NUCLEI; MEDICINE; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIOISOTOPES; TOMOGRAPHY

Optional Information

Copyright
Copyright (c) 2017 The Author(s)