Published 2008
| Version v1
Journal article
Identification of 2-[2-nitro-4-(trifluoromethyl)benzoyl]-cyclohexane-1,3-dione metabolites in urine of patients suffering from tyrosinemia type I with the use of 1H and 19F NMR spectroscopy
- 1. Faculty of Chemistry, Warsaw University of Technology, Warsaw (Poland)
- 2. Department of Biochemistry and Experimental Medicine, Children's Memorial Health Institute, Warsaw (Poland)
Description
Organic extracts of six urine samples from children treated with nitisinone, a medicine against tyrosinemia type I, were investigated by 1H and 19F NMR spectroscopy. The presence of unchanged 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC), 6-hydroxy-2-[2-nitro- 4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC-OH) and 2-nitro-4-trifluoromethylbenzoic acid (NTFA) as well as a few other unidentified compounds containing CF3 group was documented. (authors)
Additional details
Publishing Information
- Journal Title
- Acta Biochimica Polonica
- Journal Volume
- 55
- Journal Issue
- 4
- Journal Page Range
- p. 749-752
- ISSN
- 0001-527X
INIS
- Country of Publication
- Poland
- Country of Input or Organization
- Poland
- INIS RN
- 40022939
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CHILDREN; DIAGNOSIS; FLUORINE 19; HYDROGEN 1; METABOLITES; NMR SPECTRA; PATIENTS; URINARY TRACT; URINE
- Descriptors DEC
- AGE GROUPS; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; FLUORINE ISOTOPES; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAMMALS; MAN; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PRIMATES; SPECTRA; STABLE ISOTOPES; VERTEBRATES; WASTES
Optional Information
- Notes
- 17 refs., 2 tabs.