Published August 1989 | Version v1
Journal article Metadata-only

Administration of interleukin 2 to a child with stage IV neuroblastoma after chemotherapy, therapy with 131iodo metaiodobenzyl-guanidine (mIBG), and bone marrow transplantation

Creators

  • 1. Tuebingen Univ. (Germany, F.R.). Abt. fuer Nuklearmedizin
  • 2. Tuebingen Univ. (Germany, F.R.). Kinderklinik
  • 3. Tuebingen Univ. (Germany, F.R.). Medizinische Klinik

Description

Significant tumor regression was achieved after two courses of IL2 in a 4 year old boy with a stage IV neuroblastoma. IL2 altered the characteristics of tumor cells resulting in changed m-IBG kinetics in the infiltrated bone marrow. After three months and three IL2 courses a tumor progression was indicated by the growth of pelvine lymph nodes. (orig.)

Abstract (German)

IL-2 bietet sich als Chance fuer die Tumortherapie an. Nach zwei Therapiebloecken mit IL-2 wurde bei einem 4 Jahre alten Jungen mit Neuroblastom Stadium IV eine deutliche Tumorregression erreicht. IL-2 aendert die Eigenschaften der Tumorzellen, wodurch im befallenen Knochenmark eine geaenderte Kinetik des m-IBG bewirkt wird. Nach drei Monaten und drei IL-2 Bloecken zeigte das Wachstum von Leistenlymphknoten eine Tumorprogression an. (orig.)

Additional details

Additional titles

Subtitle (English)
Case report
Original title (German)
Anwendung von Interleukin 2 bei einem Kind mit Stadium IV Neuroblastom nach Chemotheraphie, Therapie mit
Original subtitle (German)
Fallbericht.

Publishing Information

Journal Title
Nuc Compact
Journal Volume
20
Journal Issue
4
Series
Nuc Compact.
Journal Page Range
138-141
ISSN
0344-3752
CODEN
CNNMA

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
21010635
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BONE MARROW; BRAIN; CHILDREN; DIAGNOSIS; GUANIDINES; IODINE 123; LYMPHOKINES; METASTASES; NEOPLASMS; NERVOUS SYSTEM DISEASES; ORGANIC IODINE COMPOUNDS; PATIENTS; RADIOPHARMACEUTICALS; SCINTISCANNING; THERAPY; TUMOR CELLS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBONIC ACID DERIVATIVES; CENTRAL NERVOUS SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEMATOPOIETIC SYSTEM; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MAN; MATERIALS; MEDICINE; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TISSUES; VERTEBRATES