Published April 2, 1986
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Recent progress with the DNA repair mutants of Chinese hamster ovary cells
Description
Repair deficient mutants of Chinese hamster ovary (CHO) cells are being used to identify human genes that correct the repair defects and to study mechanisms of DNA repair and mutagenesis. Five independent tertiary DNA transformants were obtained from the EM9 mutant. In these clones a human DNA sequence was identified that correlated with the resistance of the cells to CldUrd. After Eco RI digestion, Southern transfer, and hybridization of transformant DNAs with the BLUR-8 Alu family sequence, a common fragment of 25 to 30 kb was present. 37 refs., 4 figs., 3 tabs
Availability note (English)
MF available from INIS under the Report Number; Available from NTIS, PC A03/MF A01; 1 as DE86010564.Files
18001793.pdf
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Additional details
Publishing Information
- Imprint Pagination
- 31 p.
- Report number
- UCRL--94305
Conference
- Title
- Conference on molecular biology of DNA repair.
- Dates
- 16-18 Apr 1986.
- Place
- Manchester (UK).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18001793
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference, Numerical Data
- Descriptors DEI
- BIOCHEMISTRY; CHO CELLS; DNA REPAIR; DNA-CLONING; ELECTROPHORESIS; EXPERIMENTAL DATA; GENE MUTATIONS; GENE RECOMBINATION; SISTER CHROMATID EXCHANGES; ULTRAVIOLET RADIATION
- Descriptors DEC
- ANIMAL CELLS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; CHEMISTRY; CLONING; DATA; ELECTROMAGNETIC RADIATION; INFORMATION; MUTATIONS; NUMERICAL DATA; RADIATIONS; SOMATIC CELLS
Optional Information
- Notes
- Portions of this document are illegible in microfiche products.
- Secondary number(s)
- CONF-8604183--1.