Published 1990 | Version v1
Book Metadata-only

Labelling and purification of DTPA-coupled monoclonal antibodies with 57Co, 90Y and 165Dy

Creators

  • 1. Valtion Teknillinen Tutkimuskeskus, Espoo (Finland)
  • 2. Technical Research Centre of Finland, Espoo (Finland). Reactor Lab.
  • 3. Helsinki Univ. Central Hospital (Finland). Meilahti Clinic

Description

Commercially available antibodies were labelled, with 57Co, 90Y and 165Dy via DTPA chelation. If pure enough isotopes and other materials are available, reasonably high specific activities can routinely be obtained (to 1 - 30% of theoretical maximum) in this study. Purification methods for 57Co and 90Y are discussed. Also a rapid, reliable and simple method for labelled antibody purification is described. 6 refs., 1 fig

Additional details

Publishing Information

Publisher
Wollongong University Printery Services.
Imprint Place
Wollongong (Australia)
ISBN
0 642 59902 5
Imprint Title
Advances in radiopharmacology: proceedings of the six international symposium on radiopharmacology
Imprint Pagination
314 p.
Journal Page Range
p. 227-237.

Conference

Title
6. International symposium on radiopharmacology.
Dates
24-26 Aug 1989.
Place
Sydney (Australia).

INIS

Country of Publication
Australia
Country of Input or Organization
Australia
INIS RN
22018585
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ACTIVITY LEVELS; ANTIGEN-ANTIBODY REACTIONS; COBALT 57; DTPA; DYSPROSIUM 165; IMMUNOTHERAPY; LABELLING; MONOCLONAL ANTIBODIES; PURIFICATION; YTTRIUM 90
Descriptors DEC
AMINO ACIDS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHELATING AGENTS; COBALT ISOTOPES; DAYS LIVING RADIOISOTOPES; DRUGS; DYSPROSIUM ISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RARE EARTH NUCLEI; RESPONSE MODIFYING FACTORS; THERAPY; YTTRIUM ISOTOPES