Published June 1974 | Version v1
Journal article Metadata-only

The influence of naproxen on DNA synthesis and DNA repair in human lymphocytes

Creators

  • 1. Graz Univ. (Austria). Klinik fuer Interne Medizin
  • 2. Krankenhaus der Stadt Wien-Lainz (Austria). 2. Medizinische Abt.
  • 3. Oesterreichische Studiengesellschaft fuer Atomenergie G.m.b.H., Seibersdorf. Inst. fuer Biologie

Description

The effect of 2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen, CG 3117) on semiconservative DNA-synthesis and DNA-repair in human lymphocytes was investigated. It was shown that there was no inhibition of DNA-synthesis and only a slight decrease in the repair capacity. (orig.)

Abstract (German)

In der vorliegenden Arbeit wurde die Wirkung von 2-(6'-Methoxy-2'-naphthyl)-propionsaeure (Naproxen, CG 3117) auf die semikonservative DNS-Synthese und DNS-Reparatur menschlicher Lymphozyten geprueft. Dabei zeigte sich, dass diese Substanz keine Hemmung der DNS-Synthese bewirkt, es trat lediglich eine geringere Verminderung der Repairkapazitaet auf. (orig.)

Additional details

Additional titles

Original title (German)
Ueber den Einfluss von Naproxen auf die DNS-Synthese und DNS-Reparatur menschlicher Lymphozyten

Publishing Information

Journal Title
Arzneim.-Forsch.
Journal Volume
24
Journal Issue
6
Series
Arzneim.-Forsch.
Journal Page Range
960-961

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
8283732
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL REPAIR; CELL CYCLE; DNA; DNA REPLICATION; DRUGS; LYMPHOCYTES; MOLECULAR STRUCTURE; RHEUMATIC DISEASES; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ULTRASTRUCTURAL CHANGES
Descriptors DEC
ANIMAL CELLS; AZINES; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; ISOTOPE APPLICATIONS; LEUKOCYTES; MORPHOLOGICAL CHANGES; NUCLEIC ACID REPLICATION; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RIBOSIDES; SKELETAL DISEASES; SOMATIC CELLS

Optional Information

Notes
1 fig.; 9 refs.