Published February 2005
| Version v1
Journal article
Radiation-induced damage to cellular DNA: measurement and biological role
- 1. Laboratoire des Lesions des Acides Nucleiques, SCIB/DRFMC, CEA/Grenoble, F-38054 Grenoble Cedex 9 (France)
Description
Emphasis is placed in this short review on recent developments concerning several aspects of the chemical and biochemical effects of ionizing radiation on both isolated and cellular DNA. This includes the mechanism of formation of single and tandem DNA lesions upon one-electron oxidation and one hydroxyl radical hit only. Information is also provided on the specificity of DNA repair enzymes and the measurement of radiation-induced damage in cellular DNA
Additional details
Identifiers
- DOI
- 10.1016/j.radphyschem.2003.12.059;
- PII
- S0969-806X(04)00510-9;
Publishing Information
- Journal Title
- Radiation Physics and Chemistry (1993)
- Journal Volume
- 72
- Journal Issue
- 2-3
- Journal Page Range
- p. 293-299
- ISSN
- 0969-806X
- CODEN
- RPCHDM
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 36063904
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CHEMICAL RADIATION EFFECTS; DNA; DNA DAMAGES; DNA REPAIR; ELECTRONS; ENZYMES; HYDROXYL RADICALS; IONIZING RADIATIONS; MUTAGENESIS
- Descriptors DEC
- BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; ELEMENTARY PARTICLES; FERMIONS; LEPTONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; RADIATION EFFECTS; RADIATIONS; RADICALS; REPAIR
Optional Information
- Copyright
- Copyright (c) 2004 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.