Enhanced erythropoietin and suppression of γ-glutamyl trans-peptidase (GGT) activity in murine lymphoma following administration of vanadium
Creators
- 1. Division of Biochemistry, Department of Pharmaceutical Tchnology, Jadavpur University, 700032 Calcutta (India)
Description
Administration of vanadium as ammonium mono-vanadate (0.005 μg/0.1 ml/mouse/day) was found to reduce the tumor cell proliferation in the host mice bearing Dalton's lymphoma. The high activity of γ-glutamyl trans-peptidase (CCT), a neoplastic marker, was seen in the host cells bearing lymphoma. Vanadium effectively prevented an increase in activity of γ-glutamyl trans-peptidase and maintained a sustained low activity of this enzyme. In addition, an improvement of the hematological aspects of the mice and almost fourfold elevation of erythropoietin (Epo) was obtained following vanadium treatment. This in Epo activity may play a vital role in regulating the growth of cellular neoplasia. The present study further confirms the anti-tumorigenic potential of vanadium in the control of tumor progression in lymphoma via modulating several factors involving erythropoiesis and may emerge as a new chemo-preventive agent for the future. (author)
Additional details
Publishing Information
- Journal Title
- Neoplasma
- Journal Volume
- 41
- Journal Issue
- 5
- Journal Page Range
- p. 291-296
- ISSN
- 0028-2685
INIS
- Country of Publication
- Slovakia
- Country of Input or Organization
- Slovakia
- INIS RN
- 29060784
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- CELL PROLIFERATION; CHEMOTHERAPY; ERYTHROPOIETIN; EXPERIMENTAL DATA; GROWTH FACTORS; HEMATOLOGY; HEMOGLOBIN; IRON 59; LABELLED COMPOUNDS; LABELLING; LYMPHOMAS; NONSPECIFIC PEPTIDASES; NUCLEAR MEDICINE; RADIONUCLIDE KINETICS; TRACER TECHNIQUES; TUMOR CELLS; UPTAKE; VANADATES; VANADIUM
- Descriptors DEC
- ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; DATA; DAYS LIVING RADIOISOTOPES; DISEASES; ELEMENTS; ENZYMES; EVEN-ODD NUCLEI; GLOBINS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROLASES; IMMUNE SYSTEM DISEASES; INFORMATION; INTERMEDIATE MASS NUCLEI; IRON ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; MEDICINE; METALS; MITOGENS; NEOPLASMS; NUCLEI; NUMERICAL DATA; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXYGEN COMPOUNDS; PEPTIDE HYDROLASES; PIGMENTS; PORPHYRINS; PROTEINS; RADIOISOTOPES; THERAPY; TRANSITION ELEMENT COMPOUNDS; TRANSITION ELEMENTS; VANADIUM COMPOUNDS
Optional Information
- Notes
- 2 figs., 2 tabs., 36 refs.