Published February 2014 | Version v1
Journal article Metadata-only

Radioprotective effects of sodium borocaptate on acute radiation-injured mice

Creators

  • 1. Naval Medical Research Institute, Shanghai (China)

Description

Objective: To investigate the radioprotective effects of sodium borocaptate on acute radiation-injured mice. Methods: BSH was administrated in peritoneal injection with 0.2 ml/20 g. Mice were exposed wholely to 60Co γ-ray with the dose of 6 Gy (0.8 Gy/min). The count of peripheral blood cells was detected at 3rd. 14th day after irradiation. Organ index was detected at 14th day after irradiation. Results: Compared to model control group, PLT of BSH (80 mg/kg) group increased significantly (P < 0.05) at 3rd day after irradiation. PLT, spleen index and thymus index increased significantly (P < 0.01, P < 0.05) at 14th day after irradiation. Conclusion: The results showed that BSH had protective effects on PLT and immune system of acute radiation-injured mice. (authors)

Additional details

Publishing Information

Journal Title
Chinese Journal of Radiological Health
Journal Volume
23
Journal Issue
1
Journal Page Range
p. 47-49
ISSN
1004-714X

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
51068165
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ACUTE IRRADIATION; BLOOD CELLS; COBALT 60; COMPARATIVE EVALUATIONS; INJECTION; IRRADIATION; MICE; RADIATION DOSES; RADIATION INJURIES; RADIATION PROTECTION; SODIUM; SPLEEN; THYMUS
Descriptors DEC
ACUTE EXPOSURE; ALKALI METALS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BODY; BODY FLUIDS; COBALT ISOTOPES; DISEASES; DOSES; ELEMENTS; EVALUATION; INJURIES; INTAKE; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LYMPHATIC SYSTEM; MAMMALS; MATERIALS; METALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
3 tabs., 16 refs.