Published 2021 | Version v1
Journal article Metadata-only

An evaluation method of water equivalent dose for boron neutron capture therapy based on the number of OH radicals created

Creators

  • 1. National Institutes for Quantum and Radiological Science and Technology, Chiba (Japan)

Description

We have proposed a new technique for dosimetry in the accelerator-based neutron field, aiming at the estimation of therapeutic effectiveness of boron neutron capture therapy (BNCT). Coumarin-3-carboxylic acid (C3CA) solution, which is known as a famous hydroxyl radical (OH radical) scavenger, is used as a chemical dosimeter to evaluate the absorbed dose of the 10B(n,α)7Li reactions. By preparing C3CA solutions with boric acid and without it, we successfully discriminate the absorbed dose of 10B(n,α)7Li reactions from that of contaminations (i.e., fast neutrons and γ rays). (author)

Availability note (English)

Available from https://radiation-chemistry.org/kaishi/111pdf/111_13.pdf

Abstract (Japanese)

近年,加速器中性子源を用いたホウ素中性子捕捉療法(BNCT)に注目が集まっている.加速器を用いて中性子場を作製した場合,熱中性子成分の線量に加えてγ線や速中性子によるそれも考慮しなければ加速器BNCTの治療効果の推定や,正常組織への副作用の影響を見積もることができない.そのため,複雑な放射線混成場である加速器中性子場において熱中性子線量を汚染成分のそれと弁別するための手法として,ヒドロキシルラジカル(OHラジカル)の捕捉材として知られているクマリン-3-カルボン酸(C3CA)水溶液を化学線量計として用いる手法を提案する.ホウ素薬剤を添加したC3CA水溶液と添加しないそれを用意し,OHラジカルの生成量とγ線のG値より10B(n,α)7Li反応によるγ線等価線量を汚染成分によるそれと区別して評価した.C3CAを化学線量計として用いることで,従来の方法よりも簡便に10B(n,α)7Li反応によるγ線等価線量を決定可能であることを示した.(著者)

Additional details

Additional titles

Original title (Japanese)
ホウ素中性子捕捉療法に資する水等価線量の測定手法の確立.OH ラジカル生成量を基準として

Identifiers

URL
https://radiation-chemistry.org/kaishi/111pdf/111_13.pdf;

Publishing Information

Journal Title
Hoshasen Kagaku (Online)
Journal Issue
no.111
Series
雑誌名:放射線化学
Journal Page Range
p. 13-17
ISSN
2188-0115

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
54048686
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S61: RADIATION PROTECTION AND DOSIMETRY;
Descriptors DEI
ABSORBED RADIATION DOSES; ACCELERATOR EXPERIMENTAL FACILITIES; BIOLOGICAL RADIATION EFFECTS; BORON 10 TARGET; CARBOXYLIC ACIDS; CHEMICAL DOSEMETERS; COUMARIN; DNA DAMAGES; HYDROXYL RADICALS; NEUTRON CAPTURE THERAPY; NEUTRON REACTIONS; RADIOLYSIS
Descriptors DEC
ANTICOAGULANTS; BARYON REACTIONS; BIOLOGICAL EFFECTS; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; DECOMPOSITION; DOSEMETERS; DOSES; DRUGS; ESTERS; HADRON REACTIONS; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC OXYGEN COMPOUNDS; LACTONES; MEASURING INSTRUMENTS; MEDICINE; NEUTRON THERAPY; NUCLEAR MEDICINE; NUCLEAR REACTIONS; NUCLEON REACTIONS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PYRANS; RADIATION DOSES; RADIATION EFFECTS; RADICALS; RADIOLOGY; RADIOTHERAPY; TARGETS; THERAPY

Optional Information

Notes
12 refs., 4 figs., 1 tab.