A phytochemical study of he plant Milleria Quinqueflora L

Separation and identification gives thirteen lactones sesquiterpenicas of the plant Milleria Quinqueflora L. gathered in Alajuela in February 1997 was carried out. This is achievement by means of the extraction gives the parts you aerate puffs the plant, followed chromatographic separations. The structures the compounds they were determined by means of spectroscopy nuclear magnetic resonance (NMR), spectrometry chemical ionization with isobutane (CIMS) and molecular shaping. In a first separation, eleven lactones were obtained, give which eight had already been reported for this plant. It is believed that the three remaining they were formed devices during the evaporation gives the mobile phase metanol/water used in the chromatography on the reverse phase. We gathered the plant in Turrialba again, in February 1998 was repeated the separation without using this type chromatography. This time the supposed devices were not detected and two new compounds were obtained that could have reacted with the methanol to form the devices. The biological activities give the thirteen compounds they were determined by investigators the department Pharmaceutical Biology the University Friburgo, Germany. We conclude that these compounds have a high antiinflammatory activity when inhibiting the factor transcription NF-Kb to concentrations micromolares. (Author)