Radioprotective effect of IL-2 and IL-6 on induction of apoptosis in cells by enriched uranium
Description
Studies on apoptosis in lymph e cell line Molt-4 and macrophage cell line Ana-1 induced by 235U and the radioprotection of IL-2 and IL-6. The cumulative radiation absorption doses of 235U in cultured cells through different periods were estimated. The microautoradiographic study showed that at first 235U was phagocytized by Molt-4 and Ana-1 cells, and then 235U was penetrated into nucleus. The morphological changes in Molt-4 and Ana-1 cells were observed by fluorescence microscopy. The authors found that cells irradiated by enriched uranium 235U displayed a significant nuclear fragmentation and pyknosis. The finding indicated that 235U can significantly increase the DNA fragmentation as well as apoptotic bodies formation in cells, and these effects could be inhibited by IL-2 and IL-6. So both IL-2 and IL-6 showed radioprotective effect on induction of apoptosis in cells by enriched uranium 235U
Additional details
Publishing Information
- Imprint Title
- Proceedings of the national conference on radiation protection
- Imprint Pagination
- 486 p.
- Journal Page Range
- p. 143-146
Conference
- Title
- National conference on radiation protection
- Dates
- 16-20 Nov 1998
- Place
- Shenzhen (China)
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 36021367
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference, Non-conventional Literature
- Descriptors DEI
- APOPTOSIS; AUTORADIOGRAPHY; DNA; ENRICHED URANIUM; LYMPHOCYTES; LYMPHOKINES; MACROPHAGES; MICROSCOPY; MORPHOLOGICAL CHANGES; RADIATION DOSES; RADIATION PROTECTION; RADIOINDUCTION; RADIOPROTECTIVE SUBSTANCES; STRAND BREAKS; URANIUM 235
- Descriptors DEC
- ACTINIDE NUCLEI; ACTINIDES; ALPHA DECAY RADIOISOTOPES; ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DNA DAMAGES; DOSES; DRUGS; ELEMENTS; EVEN-ODD NUCLEI; GROWTH FACTORS; HEAVY NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE ENRICHED MATERIALS; ISOTOPES; LEUKOCYTES; MATERIALS; METALS; MINUTES LIVING RADIOISOTOPES; MITOGENS; NUCLEI; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PHAGOCYTES; PROTEINS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; SOMATIC CELLS; SPONTANEOUS FISSION RADIOISOTOPES; URANIUM; URANIUM ISOTOPES; YEARS LIVING RADIOISOTOPES