Published 1959 | Version v1
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Study of a case of essential hypoproteinaemia using the isotopes 131I and 15N

Creators

  • 1. Hopital des Enfants Malades, 75 - Paris (France)
  • 2. Commissariat a l'Energie Atomique, Saclay (France).Centre d'Etudes Nucleaires

Description

Hypoproteinaemia both human and experimental has been studied with the help of nuclear labelling. A comparative study has been made of the fate of serum proteins labelled by an endogenous path after administration of nitrogen-15 glycine and also of serum albumin labelled by exogenous path using iodine-131. We have determined the biological period of the serum albumin and serum globulins and also the magnitude of the vascular and extravascular pools of serum albumin. In this way it has been possible to measure the speed of replacement of plasma proteins. A presentation of results taken from both clinical observation and experiment leads to a discussion on the pathogenic mechanism of hypoproteinaemia. (author)

Availability note (English)

Available from INIS in electronic form

Abstract (French)

Les hypoproteinemies humaine et experimentale ont ete explorees a l'aide d'indicateurs nucleaires. Une etude comparative du devenir des proteines seriques marquees par voie endogene, apres administration de glycocolle-15N et de l'albumine serique marquee par voie exogene a l'iode-131 a ete realisee. On a determine la periode biologique de la serumalbumine et des globulines seriques ainsi que la grandeur des 'pools' vasculaire et extravasculaire de la serumalbumine. Il a ete ainsi possible d'evaluer la vitesse de renouvellement des proteines plasmatiques. La confrontation des resultats tires de l'observation clinique et de l'experimentation conduit a une discussion sur le mecanisme pathogenique de l'hypoproteinemie. (auteur)

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Additional details

Additional titles

Original title (French)
Etude a l'aide des isotopes

Publishing Information

Imprint Pagination
11 p.
Report number
CEA-R--1216

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
38094213
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ALBUMINS; BIOLOGICAL PATHWAYS; BIOSYNTHESIS; BLOOD SERUM; BLOOD-PLASMA CLEARANCE; CLINICAL TRIALS; GLOBULINS; GLYCINE; IODINE 131; LABELLED POOL TECHNIQUES; LABELLING; METABOLIC DISEASES; METABOLISM; NITROGEN 15; PATHOGENESIS
Descriptors DEC
AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; CARBOXYLIC ACIDS; CLEARANCE; DAYS LIVING RADIOISOTOPES; DISEASES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MATERIALS; NITROGEN ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; STABLE ISOTOPES; SYNTHESIS; TESTING; TRACER TECHNIQUES

Optional Information

Notes
14 refs.