Published October 1979 | Version v1
Journal article Metadata-only

Cutaneous permeability 'in vitro'

Creators

  • 1. Institut National de Recherche et de Securite, Service Chimie-Toxicologie, Centre de recherche, 54 - Vandoeuvre-les-Nancy (France)

Description

Using the isolated skin technique, a comparative study was undertaken in post mortem specimens of human skin and from biopsy specimens of monkeys, pigs, rabbits, guinea-pigs and hairless rats. With 14C-labeled methanol, the authors have experimentally observed that the penetration was quite similar through the skin of men and hairless rats. 14C-methanol was less penetrant in all other species and was minimal in pigs. Mathematical analysis of experimental data confirmed this observation. Microscopic autoradiographic examinations indicated 14C-localizations. This preliminary investigation determined an animal model for estimating skin permeability and will be used for further comparative and systematic experiments with industrial solvents

Abstract (French)

Les auteurs ont utilise la technique de la peau isolee pour l'etude de la permeabilite cutanee chez l'homme (prelevement post-mortem) et chez plusieurs especes animales (primate, porc, lapin, cobaye, rat mutation atrichis). Avec le 14C-methanol comme produit de reference, ils ont experimentalement observe que le rat mutation atrichis avait une permeabilite voisine de celle de l'homme alors que celle du porc etait minimale. Cette constatation a ete confirmee par l'analyse mathematique du phenomene. Des autohistoradiographies ont ete effectuees afin de localiser le radio-carbone. Les resultats sont discutes par rapport aux donnees de la litterature. Cette etude prealable permettra une etude systematique comparative des solvants industriels

Additional details

Additional titles

Original title (French)
Permeabilite cutanee 'in vitro'. Choix experimental d'un modele animal

Publishing Information

Journal Title
Arch. Mal. Prof. Med. Trav. Secur. Soc.
Journal Volume
40
Journal Issue
10
Series
Arch. Mal. Prof. Med. Trav. Secur. Soc.
Journal Page Range
927-938
ISSN
0003-9691

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
11541158
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CARBON 14 COMPOUNDS; COMPARTMENTS; IN VITRO; MATHEMATICAL MODELS; METHANOL; SKIN ABSORPTION
Descriptors DEC
ALCOHOLS; CARBON COMPOUNDS; HYDROXY COMPOUNDS; ORGANIC COMPOUNDS; UPTAKE