Published January 2012
| Version v1
Journal article
Effect of quercetin and 17-AAG on radiosensitivity of rat peripheral blood lymphocyte
Creators
- 1. School of Radiation Medicine and Public Health, Medical College of Soochow University, Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Suzhou (China)
Description
To investigate the effect of quercetin and 17-AAG on proliferation and on radiosensitivity of blood lymphocyte cells. CCK-8 assay is performed to evaluate the cytotoxicity of Quercetin on proliferation of blood lymphocyte cells. CCK-8 assay employed to observe its effects on the radiosensitivity of the cells quantified by calculating the sensitive enhancement ratio (SER). CCK-8 results showed that the inhibition of Quercetin on the cells was the dose-dependent and time-dependent, and the results of assay showed the inhibition of 17-AAG on blood lymphocyte cells was the dose-dependent and time-dependent. The study showed that Quercetin and 17-AAG have no effect on the radiosensitivity of the blood lymphocyte cells. (authors)
Additional details
Publishing Information
- Journal Title
- Radiation Protection (Taiyuan)
- Journal Volume
- 32
- Journal Issue
- 1
- Journal Page Range
- p. 28-33
- ISSN
- 1000-8187
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 45068548
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Quality check status
- Yes
- Descriptors DEI
- CELL PROLIFERATION; INHIBITION; LYMPHOCYTES; QUERCETIN; RADIATION DOSES; RADIOSENSITIVITY; RADIOSENSITIZERS; RATS; TIME DEPENDENCE; TOXICITY;
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; AROMATICS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DOSES; DRUGS; FLAVONES; FLAVONOIDS; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC OXYGEN COMPOUNDS; HYDROXY COMPOUNDS; LEUKOCYTES; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PHENOLS; POLYPHENOLS; PYRANS; RESPONSE MODIFYING FACTORS; RODENTS; SENSITIVITY; SOMATIC CELLS; VERTEBRATES;
Optional Information
- Notes
- 5 figs., 20 refs.