Multi-detector computed tomography (MDCT) findings of chemotherapy induced hepatic changes

To evaluate the role of multi-detector computed tomography (MDCT) i detection and characterization of chemotherapy induced hepatic changes Materials and methods: This retrospective study included 400 patients with confirmed 1 malignancies and treated by standard chemotherapy regimens. The most common malignancy was non-Hodgkin lymphoma and mostly chemotherapy regimen was Cyclophosphamide Hydroxydaunomycin, Oncovin and Prednisolone (CHOP). All patients underwent CT scan using 64 MDCT scanner (Brilliance 64, Philips) before chemotherapy and follow-up after 6 months fro last session of chemotherapy. Precontrast series and post-contrast triphasic study were done for al patients. All the patients underwent radiological evaluation for hepatic changes after chemotherapy treatment. All CT scans were evaluated for fatty liver, capsular retraction, veno occlusive disease and biliary sclerosis. Four patients with capsular retraction underwent liver biopsy Results: Forty patients (32 females and 8 males) had hepatic changes due to effect of chemotherapy. The most common CT finding was fatty liver. Hepatic fatty changes were detected in 36/4 patients. These fatty changes were diffuse, focal fatty and diffuse with fatty spare area. Four patients had capsular retraction: 1 patient with HD and 3 patients with metastatic cancer breast Veno-occlusive disease and biliary sclerosis were not detected