Effect of systemic DTPA treatment on tissue retention of free and carrier-bound 111In from labelled proteins and polymer

The effect of systemic treatment with DTPA on the whole body retention and biodistribution of 111In from labelled albumin, γ-globulin and a synthetic polylysine has been examined in mice. Although treatment greatly accelerated clearance of free 111In, it had much less effect on the biodistribution of the tracer from labelled materials, over and above what was probably due to free 111In in the preparations. This suggests that systemic treatment with DTPA is unlikely to have a major impact on target discrimination during scintigraphy with 111In labelled radiopharmaceuticals, such as monoclonal antibodies. (author)