Function of the kidneys and their hormonal regulation in uterine body cancer patients in pre- and postoperative periods by the results of radionuclide investigations

Methods of radionuclide renography with 131I-hippuran and a radioimmunoassay determining plasma renin activity, the level of aldosterone and cortisol were employed to study function of the kidneys and the system of the hormonal regulation of renal functions in 40 uterine body cancer patients in the time course of surgical treatment. It was established that the patients had basal intrarenal urodynamic disturbances and elevated renin activity. Unfavorable effects of surgical intervention occurred more frequently on the 1st day in the postoperative period when the presence of latent renal insufficiency could be detected by radionuclide methods. The process of renal function recovery was observed however it was determined by the level of preoperative disorders and did not reach the normal. There was correlation between an increase in renin activity and disturbances in intrarenal urodynamics in surgical treatment of uterine body cancer patients