Published 1978
| Version v1
Journal article
Effect of calcium pyrrolidon carboxylate on macromolecule formation in bone matrix
Creators
Description
14C- and 45Ca labelled calcium pyrrolidon carboxylate (PCA-Ca) was given orally to rats. The incorporated radioactivity and the nature of the radioactive aminoacids were determined in various tissues. The incorporation of 14C-PCA-Ca and its transformation products was more intense in liver and bones than in other organs. 45Ca incorporation was the strongest in the bones. An important fraction of PCA was transformed in proline and hydroxyproline in the bones and skin. Incorporation studies 14C-proline and 35SO4Na2 in fracture callus of rat indicated an activation of protein as well as of glycosaminoglycan metabolism after calcium pyrrolidon carboxylate administration
Abstract (French)
On a administre per os a des rats du pyrrolidone carboxylate de calcium marque au 14C et au 45Ca. On a determine dans differents tissus, la radioactivite incorporee et la nature des aminoacides radioactifs. L'incorporation de 14C-PCA-Ca et de ses produits de transformation etait plus intense dans le foie et les os que dans les autres organes. L'incorporation de 45Ca etait plus elevee dans les os. Une fraction importante de PCA etait transformee en proline et hydroxyproline dans les os et la peau. Les etudes d'incorporation de 14C-proline et de 35SO4Na2 dans les cals osseux de rat ont montre une activation des proteines aussi bien que du metabolisme des glycosamino-glycannes apres administration de pyrrolidonecarboxylate de calciumAdditional details
Additional titles
- Original title (French)
- Etude de l'effet du pyrrolidonecarboxylate de calcium sur la formation des macromolecules de la matrice osseuse
Identifiers
- DOI
- 10.1051/rnd:19780116;
Publishing Information
- Journal Title
- Annales de Biologie Animale Biochimie Biophysique
- Journal Volume
- 18
- Journal Issue
- 1
- Series
- Ann. Biol. Anim. Biochim. Biophys.
- Journal Page Range
- 133-136
- ISSN
- 0003-388X
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 9414614
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOSYNTHESIS; BONE TISSUES; CALCIUM COMPOUNDS; CALCIUM 45; CARBON 14 COMPOUNDS; CARBOXYLIC ACIDS; METABOLISM; PROTEINS; PYRROLIDONES; RATS; TRACER TECHNIQUES
- Descriptors DEC
- ALKALINE EARTH METAL COMPOUNDS; AMIDES; ANIMALS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CALCIUM ISOTOPES; CARBON COMPOUNDS; CONNECTIVE TISSUE; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; LACTAMS; MAMMALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRROLES; RADIOISOTOPES; RODENTS; SYNTHESIS; TISSUES; VERTEBRATES
Optional Information
- Notes
- Updated automatically by Metadata and Full-Text Enrichment Agent