Published June 1985
| Version v1
Journal article
Adriamycin does not affect the repair of X-ray induced DNA single strand breaks
Creators
- 1. Universita degli Studi de Urbino, Urbino (Italy), Instituto di Farmacologia e Farmacognosia
Description
The ability of the antitumor antibiotic adriamycin (Ad) to inhibit the rejoining of DNA single strand breaks produced by X-rays was investigated in cultured cells. Chinese hamster ovary cells were given 400 rad and were allowed to repair in the presence or absence of Ad for 60 min at 37degC. The drug did not affect the ability of cells to repair DNA breaks and residual breaks found after the repair period were attributed to those induced by Ad alone. (author)
Additional details
Publishing Information
- Journal Title
- Cancer Lett.
- Journal Volume
- 27
- Journal Issue
- 2
- Series
- Cancer Lett.
- Journal Page Range
- 215-219
- ISSN
- 0304-3835
INIS
- Country of Publication
- Ireland
- Country of Input or Organization
- Ireland
- INIS RN
- 16084627
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL REPAIR; CELL CULTURES; DNA; DOXORUBICIN; INHIBITION; RADIATION DOSES; STRAND BREAKS; X RADIATION
- Descriptors DEC
- ANTIBIOTICS; ANTINEOPLASTIC DRUGS; BIOLOGICAL RECOVERY; DRUGS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATIONS
Optional Information
- Notes
- 16 refs.