Interest of X-ray computed tomography and NMR tomography for the early diagnosis of acute localized irradiation. Experimental study in pigs
Creators
- 1. C.E.A., 78 - Jouy-en-Josas (France). Lab. de Radiobiologie Appliquee
- 2. L.R.A., Domaine de Vilvert, 78 - Jouy-en-Josas (France)
Description
Investigations were performed on 4 pigs, between 1 and 14 days after acute localized irradiation (with 192Ir) by X-ray computed tomography and NMR tomography. Areas irradiated with doses higher than 40 Gy could be visualized very early (on the 4th day) when no appearent lesions could be seen on histological samples according to classical pathology. Irradiated tissues at this high dose level are to necrose and surgery is the only practicable treatment. Therefore up to now that technique appears to be the only reliable one that could be used for an early and accurate assessment of the damages. Accordingly it should be suitable for pertinent surgical treatment. Further investigations are necessary to set more close relations between imaging, pathology and dose
Abstract (French)
Apres une irradiation aigue localisee chez le porc, les explorations de la region anatomique irradiee par tomographie X et RMN ont permis tres precocement (4e jour) de delimiter la zone tissulaire ayant recu plus de 40 Gy; ces tissus vont se necroser a coup sur et l'exerese chirurgicale precoce est la seule attitude therapeutique possible. A ce jour aucune autre methode de diagnostic ne permet de guider aussi precocement l'acte chirurgical. De nouvelles recherches doivent permettre d'etablir des relations plus precises entre l'imagerie, l'histologie et la dose recueAdditional details
Additional titles
- Original title (French)
- Interet de la tomographie X et RMN pour le diagnostic precoce des irradiations localisees. Etude experimentale chez le porc
Publishing Information
- Journal Title
- J. Biophys. Biomec.
- Journal Volume
- 10
- Journal Issue
- 2
- Series
- J. Biophys. Biomec.
- Journal Page Range
- 89-92
- CODEN
- JBNDD
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 18008733
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ACUTE IRRADIATION; COMPUTERIZED TOMOGRAPHY; DIAGNOSIS; EARLY RADIATION EFFECTS; IRIDIUM 192; LOCAL IRRADIATION; NMR IMAGING; RADIATION INJURIES; SWINE
- Descriptors DEC
- ACUTE EXPOSURE; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DOMESTIC ANIMALS; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; INJURIES; INTERNAL CONVERSION RADIOISOTO; IRIDIUM ISOTOPES; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; TOMOGRAPHY; VERTEBRATES; YEARS LIVING RADIOISOTOPES