Synthesis, antimalarial and antioxidant activity of coumarin appended 1,4-disubstituted 1,2,3-triazoles

A series of coumarin appended triazole hybrids of biotic interest was synthesized through click chemistry approach from the coumarin based terminal alkynes and aromatic azides. All the synthesized triazoles were characterized by FT-IR, ¹H NMR, ¹³C NMR, and HRMS and assessed for antimalarial activities against plasmodium falciparum strain. Results revealed that most of the synthesized coumarin–triazole hybrid compounds possess moderate to good activity. Further, the synthesized coumarin triazole hybrids were employed for antioxidant activities and were found to be potent antioxidant when compared with standard drug. Graphic abstract: