Induction of follistatin precedes gastric transformation in gastrin deficient mice
- 1. Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB 2051, Ann Arbor, MI 48109-2200 (United States)
- 2. Department of Molecular and Integrative Physiology, University of Michigan, 109 Zina Pitcher Place, BSRB 2051, Ann Arbor, MI 48109-2200 (United States)
Description
We previously showed that antral gastric tumors develop in gastrin-deficient (Gas-/-) mice. Therefore Gas-/-mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation. Fundic atrophy developed by 9 months in Gas-/- mice. Antral mucosal hyperplasia developed coincident with the focal loss of TFF1 and Muc5AC. Microarray analysis of 12 month Gas-/- tumors revealed an increase in follistatin, an activin/BMP antagonist. We found that elevated follistatin expression occurred in the proliferative neck zone of hyperplastic antrums, in antral tumors of Gas-/- mice, and also in human gastric cancers. Follistatin induced cyclin D1 and the trefoil factors TFF1 and TFF2 in a gastric cancer cell line. We concluded that antral hyperplasia in Gas-/- mice involves amplification of mucous cell lineages due to follistatin, suggesting its role in the development of antral gastric tumors
Availability note (English)
Available from http://dx.doi.org/10.1016/j.bbrc.2008.09.031Additional details
Identifiers
- DOI
- 10.1016/j.bbrc.2008.09.031;
- PII
- S0006-291X(08)01778-6;
Publishing Information
- Journal Title
- Biochemical and Biophysical Research Communications
- Journal Volume
- 376
- Journal Issue
- 3
- Journal Page Range
- p. 573-577
- ISSN
- 0006-291X
- CODEN
- BBRCA9
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 40085892
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ATROPHY; GASTRIN; GASTROINTESTINAL TRACT; MICE; NECK; NEOPLASMS
- Descriptors DEC
- ANIMALS; BODY; DIGESTIVE SYSTEM; DISEASES; HORMONES; MAMMALS; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PROTEINS; RODENTS; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.