The changes in levels of C-P and insulin in glucose tolerance test in rats with experimental non-insulin dependent diabetes mellitus
Creators
- 1. Jiamusi Univ., Jiamusi (China). Dept. of Physiology, Basic Medical College
- 2. Jiamusi Univ., Jiamusi (China). The Second Affiliated Hospital
Description
The changes in levels of C-P and insulin were investigated in the GT test in rats with non-insulin dependent diabetes mellitus. In order to establish a model of non-insulin dependent diabetes mellitus (NIDDM), the authors injected rats with small dose streptozocoi (i.v.). Two weeks after the injection, the rats developed impaired glucose tolerance (IGT). Then, they were fed with high energy diet for eight weeks to form NIDDM. The results showed that the highest peak time of C-P and insulin in NIDDM was remarkably later than that in normal subjects, the highest peak time was in two hours (P < 0.05). The data suggest that level of C-P could accurately respond to level of insulin, and this experimental non-insulin dependent diabetes mellitus model is ideal
Additional details
Publishing Information
- Journal Title
- Labeled Immunoassays and Clinical Medicine
- Journal Volume
- 8
- Journal Issue
- 4
- Journal Page Range
- p. 218-219
- ISSN
- 1006-1703
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 33027483
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOASSAY; BIOLOGICAL FUNCTIONS; DIABETES MELLITUS; DIAGNOSIS; GLUCOSE; INSULIN; METABOLISM; PEPTIDES; RADIOIMMUNOASSAY; RATS
- Descriptors DEC
- ALDEHYDES; ANIMALS; BIOASSAY; CARBOHYDRATES; DIAGNOSTIC TECHNIQUES; DISEASES; ENDOCRINE DISEASES; HEXOSES; HORMONES; IMMUNOASSAY; ISOTOPE APPLICATIONS; MAMMALS; METABOLIC DISEASES; MONOSACCHARIDES; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; RODENTS; SACCHARIDES; TRACER TECHNIQUES; VERTEBRATES