Published July 1983 | Version v1
Journal article Metadata-only

Enhanced lethal effect of combined ACNU with x-ray on cultured HeLaS3 cells

Creators

  • 1. National Inst. of Radiological Sciences, Chiba (Japan)

Description

The combined effects of ACNU and X-irradiation on cultured HeLaS3 cells were investigated. Pretreatment with either ACNU or X-ray induced a substantial reduction in shoulder width the D0 value of the dose-response curve for the other agent, given later was unchanged. ACNU did not inhibit the recovery of sublethal damage (SLD) induced by X-ray when this treatment preceded the spilit-dose experiment. Our results indicate that some cell damage induced by each agent is transmissible to the progeny of the surviving cells and that the interaction of ACNU and X-irradiation was lethal to the cells. (author)

Additional details

Publishing Information

Journal Title
Gan No Rinsho
Journal Volume
29
Journal Issue
8
Series
Gan No Rinsho.
Journal Page Range
863-868
ISSN
0021-4949

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
15055840
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANTINEOPLASTIC DRUGS; BIOLOGICAL RADIATION EFFECTS; CELL KILLING; DOSE-RESPONSE RELATIONSHIPS; HELA CELLS; NITROSO-R SALT; RADIOSENSITIVITY; SURVIVAL CURVES; SYNERGISM; X RADIATION
Descriptors DEC
ANIMAL CELLS; AROMATICS; BIOLOGICAL EFFECTS; DRUGS; ELECTROMAGNETIC RADIATION; HYDROXY COMPOUNDS; IONIZING RADIATIONS; NAPHTHOLS; NITROSO COMPOUNDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PHENOLS; RADIATION EFFECTS; RADIATIONS; SULFONIC ACIDS; TUMOR CELLS