Modified chitosan-coated magnetic nanoparticles: exclusively for the delivery of ³²P to hepatoma cells

Radionuclides used in radiation ablation therapy of hepatocellular carcinoma (HCC) lack self-targeting and face challenges in homogenous dose distribution. ³²P, a potent β emitter with several desirable features of co-ordination with cellular biomolecules can easily overcome the challenge of dose distribution. However, a major hindrance in this direction is to effectively deliver ³²P into target tissue. This study is an attempt to successfully synthesize modified chitosan coated magnetic nanoparticles (MNPs) for the delivery of ³²P to HCC cells. Designing a polymer- ligand coated MNPs for the delivery of ³²P to hepatoma cells. ³²P labelled galactosylated chitosan-coated magnetic nanoparticles can be synthesized through similar mechanism and aimed to target hepatoma cells