Published September 10, 2020
| Version v1
Journal article
Permanent Bilateral Carotid Filters for Stroke Prevention in Atrial Fibrillation
Creators
- 1. Cardiovascular Center, OLV Hospital (Belgium)
- 2. Javelin Medical Ltd. (Israel)
- 3. Icahn School of Medicine at Mount Sinai. Helmsley Electrophysiology Center, Division of Cardiology (United States)
- 4. Homolka Hospital. Department of Cardiology (Czech Republic)
- 5. University Heidelberg. Department of Neurology (Germany)
- 6. Alfried Krupp Krankenhaus. Department of Neurology (Germany)
- 7. Imperial College London. Department of Brain Science (United Kingdom)
- 8. McMaster University. Population Health Research Institute (Canada)
Description
Purpose of Review
: A novel permanent carotid filter device for percutaneous implantation was developed for the purpose of stroke prevention. In this review, we cover rationale, existing preclinical and clinical data, and potential future directions for research using such a device.Recent Findings
: The Vine™ filter was assessed for safety in sheep and in 2 observational human studies, the completed CAPTURE 1 (n = 25) and the ongoing CAPTURE 2 (planned n = 100). CAPTURE 1 has shown high procedural and long-term implant safety. A control group was not available for comparison.Summary
: A mechanical filter for permanent stroke prevention can be implanted bilaterally in the common carotid artery safely and efficiently. A randomized trial is planned for 2021 (n = 3500, INTERCEPT) to demonstrate superiority of a filter + anticoagulation strategy over anticoagulation alone in patients at high risk for ischemic stroke.Additional details
Identifiers
Publishing Information
- Journal Title
- Current Cardiology Reports (Print)
- Journal Volume
- 22
- Journal Issue
- 11
- Journal Page Range
- vp.
- ISSN
- 1523-3782
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 55061082
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ARTERIES; BRAIN; CAROTID ARTERIES; COMPARATIVE EVALUATIONS; FILTERS; HAZARDS; IMPLANTS; ISCHEMIA; MECHANICAL FILTERS; PATIENTS; PLAQUE FORMATION; SAFETY; SHEEP
- Descriptors DEC
- ANEMIAS; ANIMALS; ARTERIES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DISEASES; DOMESTIC ANIMALS; EVALUATION; FILTERS; HEMIC DISEASES; MAMMALS; NERVOUS SYSTEM; ORGANS; RUMINANTS; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2020 © The Author(s) 2020