Preparation and comparative preclinical test of nanometre size albumin aggregates labellable with 99mTc

Human serum albumin based, nanosized colloid labellable with 99mTc-pertechnetate was developed in the form of an inactive kit (NANO-ALBUMON). Labelling efficiency at the time of production and three months later exceeded 98%. The size of colloid particles was under 100 nm and showed highly homogeneous distribution. The colloid injected intravenously is suitable for the scintigraphy of bone marrow and injected subcutaneously for the scintigraphy of lymph circulation. Animal experiments rendered evidence that the radiochemical purity, stability, particle size and biodistribution agree with those of SOLCO-NANOCOLL used as reference. The clinical testing of 99mTc-NANO-ALBUMON is under way. (author) 10 refs.; 3 figs