Core–shell fibrous membranes of PVDF–Ba_0.9Ca_0.1TiO₃/PVA with osteogenic and piezoelectric properties for bone regeneration

The goal of this research was to promote the bioactivity and osteogenic characteristics of polyvinylidene fluoride(PVDF) fibrous membrane, while preserving its piezoelectric property for bone regeneration. In this regard, core–shell fibrous membrane of PVDF–Ba_0.9Ca_0.1TiO₃/polyvinyl alcohol(PVA) was developed via emulsion electrospinning approach. While PVA was in the outer layer of fibers with thickness of 53 ± 18 nm, the Ba_0.9Ca_0.1TiO₃ nanoparticles was uniformly dispersed in the PVDF core. The formation of PVA shell resulted in significant improvement of its hydrophilicity (3 times) and degradation rate, while piezoelectricity did noticeably modulate. In addition, incorporation of Ba_0.9Ca_0.1TiO₃ nanopowder remarkably improved bioactivity, protein adsorption and mechanical properties of PVDF/PVA fibrous membranes. Finally, the osteogenic differentiation of mesenchymal stem cells on the nanocomposite fibrous membranes, in the absence of osteogenic supplements, was also observed. Overall, the results confirmed the promising potential of PVDF–Ba_0.9Ca_0.1TiO₃/PVA fibrous membrane containing 1–2 wt% nanopowder for bone regeneration. (paper)