Published November 2018 | Version v1
Journal article Metadata-only

Evidence of axonal damage in cerebellar peduncles without T2-lesions in multiple sclerosis

Creators

  • 1. Nehme and Therese Tohme Multiple Sclerosis Center, Faculty of Medicine, American University of Beirut Medical Center, Beirut (Lebanon)
  • 2. CREATIS, UMR 5220 CNRS & U1206 INSERM, Université Claude Bernard – Lyon1, Université de Lyon, Villeurbanne (France)
  • 3. Service de Neurologie A, Hôpital Neurologique Pierre Wertheimer, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron (France)
  • 4. Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite (France)
  • 5. Center for Neurological Imaging, Partners Multiple Sclerosis Center, Departments of Neurology and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)
  • 6. Département IRM, CERMEP-Imagerie du Vivant, Université de Lyon, Bron (France)

Description

Highlights: • Cerebellar DTI abnormalities reflect both local and distant pathology effect. • AD abnormalities in both non-lesioned and lesioned CP reflect early axonal damage. • Clinical and disability outcomes are associated with cerebellar DTI abnormalities. - Abstract: Background and aimCerebellar peduncles (CP) can be probed by diffusion tensor imaging (DTI) to evaluate the integrity of cerebellar afferent and efferent networks. Damage to the CP in multiple sclerosis (MS) could lead to serious cognitive and mobility impairment. The aim of this study was to investigate the extent and the clinical impact of CP damage in MS.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.ejrad.2018.09.016

Additional details

Identifiers

DOI
10.1016/j.ejrad.2018.09.016;
PII
S0720048X18303127;

Publishing Information

Journal Title
European Journal of Radiology
Journal Volume
108
Journal Page Range
p. 114-119
ISSN
0720-048X
CODEN
EJRADR

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
51002665
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BRAIN; DAMAGE; MOBILITY; NERVOUS SYSTEM DISEASES; NMR IMAGING; PATHOLOGY; SPINAL CORD; TENSORS
Descriptors DEC
BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; NERVOUS SYSTEM; ORGANS

Optional Information

Notes
© 2018 Elsevier B.V. All rights reserved.