Published February 13, 2014 | Version v1
Journal article Metadata-only

Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression

Creators

  • 1. Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 (United States)
  • 2. Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-8-15 Kuramoto, Tokushima 770-8504 (Japan)

Description

Extracellular matrix degradation by matrix metalloproteinases (MMPs) plays a pivotal role in cancer progression by promoting motility, invasion and angiogenesis. Studies have shown that MMP expression is increased in head and neck squamous cell carcinomas (HNSCCs), one of the most common cancers in the world, and contributes to poor outcome. In this review, we examine the expression pattern of MMPs in HNSCC by microarray datasets and summarize the current knowledge of MMPs, specifically MMP-1, -3, -7 -10, -12, -13, 14 and -19, that are highly expressed in HNSCCs and involved cancer invasion and angiogenesis

Availability note (English)

Available from http://dx.doi.org/10.3390/cancers6010396; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980592

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980592;
DOI
10.3390/cancers6010396;

Publishing Information

Journal Title
Cancers (Basel)
Journal Volume
6
Journal Issue
1
Journal Page Range
p. 396-415
ISSN
2072-6694

INIS

Country of Publication
Switzerland
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
47001957
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ANGIOGENESIS; CARCINOMAS; GENES; HEAD; MATRICES; NECK
Descriptors DEC
BODY; DISEASES; NEOPLASMS

Optional Information

Copyright
Copyright (c) 2014 by the authors
Notes
PMCID: PMC3980592; PMID: 24531055; PUBLISHER-ID: cancers-06-00396; OAI: oai:pubmedcentral.nih.gov:3980592; licensee MDPI, Basel, Switzerland.; This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).