Relationship between serum leptin levels, ATPase activity of erythrocyte membrance and development of diabetic nephropathy in patients with DM2
Creators
- 1. Department of Clinical Laboratory, the Traditional Chinese Medicine Hospital of Taizhou, Taizhou (China)
Description
Objective: To study the possible mechanism of development of nephrosis affected by changes of serum leptin levels and alteration of activities of Na+K+-ATPase and Ca2+Mg2+-ATPase of erythrocyte membrane in patients with type 2 diabetes(DM2). Methods: Serum leptin levels (with RIA) and erythrocyte membrane Na+K+-ATPase and Ca2+Mg2+-ATPase activitities (with Reinila method) were determined in 40 DM2 patients without nephropathy, 32 DM2 patients with nephropathy and 35 controls. Results Serum leptin levels were significantly higher in the diabetics as a whole than those in controls (P<0.01), while the RBC Na+K+-ATPase and Ca2+Mg2+-ATPase activities were significantly lower (P<0.01). Among the diabetic patients, the serum leptin levels in patients without nephrosis (P<0.05), but the RBC membrance ATPase activities were significantly lower(P<0.05). Conclusion: Development of type 2 diabetes nephrosis might be correlated with the high serum leptin level and decreased ATPase activities of erythrocite membrane. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 22
- Journal Issue
- 6
- Journal Page Range
- p. 577-579
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 42057411
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ATP-ASE; BLOOD SERUM; CALCIUM COMPOUNDS; DIABETES MELLITUS; DIAGNOSIS; ENZYME ACTIVITY; ERYTHROCYTES; KIDNEYS; LEPTIN; MAGNESIUM COMPOUNDS; MEMBRANES; PATIENTS; POTASSIUM COMPOUNDS; RADIOIMMUNOASSAY; SODIUM COMPOUNDS; UROGENITAL SYSTEM DISEASES
- Descriptors DEC
- ACID ANHYDRASES; ALKALI METAL COMPOUNDS; ALKALINE EARTH METAL COMPOUNDS; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BLOOD PLASMA; BODY; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; DISEASES; ENDOCRINE DISEASES; ENZYMES; HORMONES; HYDROLASES; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; METABOLIC DISEASES; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; PHOSPHOHYDROLASES; POLYPEPTIDES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; TRACER TECHNIQUES
Optional Information
- Notes
- 2 tabs., 10 refs.