Published April 2010 | Version v1
Journal article Metadata-only

Clinical significance of determination of changes of serum TGF-α, TGF-β1 and VEGF levels after chemotherapy in patients with lung cancer

Creators

  • 1. Department of Tumor, Ningguo Municipal People's Hospital, Ningguo (China)
  • 2. Department of Tumor, Lianyungang First People's Hospital, Lianyungang (China)

Description

Objective: To explore the clinical significance of changes of serum TGF-α, TGF-β1 and VEGF levels after chemotherapy in patients with lung cancer. Methods: Serum TGF-α, TGF-β1 (with RIA) and VEGF (with ELISA) contents were measured in 33 patients with lung cancer both before and after chemotherapy as well as in 35 controls. Results: Before chemotherapy,serum TGF-α, TGF-β1 and VEGF levels were significantly higher (P<0.01) in patients with lung cancer. After chemotherapy for 3 months, the serum TGF-α, TGF-β1 and VEGF levels dropped markedly but still remained significantly higher (P<0.05) than those in controls. Conclusion: Serum TGF-α, TGF-β1 and VEGF levels were related to the development of tumor in patients with lung cancer. (authors)

Additional details

Publishing Information

Journal Title
Journal of Radioimmunology
Journal Volume
23
Journal Issue
2
Journal Page Range
p. 140-142
ISSN
1008-9810

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
44076105
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BLOOD SERUM; BLOOD VESSELS; CARCINOMAS; CHEMOTHERAPY; DIAGNOSIS; ENDOTHELIUM; ENZYME IMMUNOASSAY; GROWTH FACTORS; LUNGS; PATIENTS; RADIOIMMUNOASSAY
Descriptors DEC
ANIMAL TISSUES; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; MEDICINE; MITOGENS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; RESPIRATORY SYSTEM; THERAPY; TRACER TECHNIQUES

Optional Information

Notes
1 tabs., 7 refs.