Research on biological effects of radioactive ion beam
Creators
- 1. National Inst. of Radiological Sciences, Chiba, Chiba (Japan)
Description
To evaluate the potential importance of a radioactive 9C-ion beam, representing a double radiation source coming from the external beam itself and the delayed particles emitted internally, in cancer therapy, radiobiological experiments using human salivary gland cells (HSG) were performed in the secondary beam line (SBL) at Heavy Ion Medical Accelerator in Chiba (HIMAC). HSG cell surviving effects at different penetration depths along a 9C-ion beam as well as a comparative therapeutic 12C beam were measured with standard clonogenic assay. The 9C beam showed an enhanced efficiency in cell killing around its Bragg-peak region compared to the counterpart 12C beam. Based on an elaborate biophysical analysis, we concluded that the enhanced biological effect was due to the delayed particles from the incident stopping 9C ions. In addition, compared to the existing data an obvious dose-rate sparing effect was exhibited for the high-linear energy transfer (LET) carbon beams. (author)
Additional details
Publishing Information
- Imprint Title
- 2004 annual report of the research project with heavy ions at NIRS-HIMAC
- Imprint Pagination
- 339 p.
- Journal Page Range
- p. 224-225
- Report number
- NIRS-M--180
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 37040903
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Non-conventional Literature
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BRAGG CURVE; CARBON 12; CARBON 9; CELL KILLING; COBALT 60; DOSE RATES; GAMMA RADIATION; HIMAC ACCELERATOR; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RBE; SALIVARY GLANDS; SURVIVAL CURVES
- Descriptors DEC
- ACCELERATORS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; CARBON ISOTOPES; COBALT ISOTOPES; CYCLIC ACCELERATORS; DIAGRAMS; DOSES; ELECTROMAGNETIC RADIATION; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; GLANDS; HEAVY ION ACCELERATORS; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MILLISECONDS LIVING RADIOISOTOPES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; STABLE ISOTOPES; SYNCHROTRONS; YEARS LIVING RADIOISOTOPES
Optional Information
- Secondary number(s)
- HIMAC--106