Published September 1988
| Version v1
Journal article
Kinetic analysis of technetium-99m d,1-HM-PAO decomposition in aqueous media
Description
Technetium-99m-d,1-hexamethylpropyleneamine oxime [/sup 99m/Tc]d,1-HM-PAO) is a neutral-lipophilic chelate formed from a kit in high yield by stannous reduction of Na/sup 99m/TcO4-. Of three methods used to analyze the purity of the /sup 99m/Tc complexes, a single strip method using ether as the developing solvent was the most rapid and simple to perform. The lipophilic chelate converts to /sup 99m/TcO4- and other hydrophilic products with time and this limits the useful lifetime of the preparations. The rate of decomposition of [/sup 99m/Tc]d,1-HM-PAO increased in the presence of excess stannous ion and at pH greater than 9
Additional details
Publishing Information
- Journal Title
- Journal of Nuclear Medicine
- Journal Volume
- 29
- Journal Issue
- 9
- Series
- J. Nucl. Med.
- Journal Page Range
- 1568-1576
- ISSN
- 0022-3123
- CODEN
- JNMEA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 20016047
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CHEMICAL ANALYSIS; COMPLEXES; DECOMPOSITION; ISOMERIC NUCLEI; ORGANOMETALLIC COMPOUNDS; OXIMES; RADIOPHARMACEUTICALS; TECHNETIUM 99; WATER
- Descriptors DEC
- AMINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; DRUGS; HOURS LIVING RADIOISOTOPES; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXYGEN COMPOUNDS; POLAR SOLVENTS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SOLVENTS; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES