The observation of neoadjuvant radiiotherapy for stage II cervical carcer

Objective: Collect the 3-years and 5-years survival rates of II cervical carcer treated by neoadjuvant radiotherapy plus radical surgery to analyse the impact of neoadjuvant radiotherapy on surgery and observe the side effects of radiotherapy to discuss the value of neoadjuvant radiotherapy to stage II cervical cancer. Methods: 109 stage II cervical cancer patients were chosen in the No.2 Hospital of Shanxi Medical University during July 2007 to April 2011. Group l(n = 59) received the preoperative neoadjuvant radiotheerapy (external beam radiation therapy and intracavitary brachyteerapy). After a rest of 2 to 3 weeks, radical hysterectomy wity pelvic lymphadenectomy was performed. Group 2 (n = 50) underwent radical radiation therapy alone. Results: There was no significant difference between 3-years and 5-years survival tates between neoadjuvant radiotherapy group and radical radiotherapy group for the short-term follow-up. 59 patients successfully received radical surgery without increasing the rate of complications. Major radiotherapy side effects in neoadjuvant radiotherapy group occurred less frequently than the in radical radiotherapy group(P < 0.05). Conclusion: Neoadjuvant radiotherapy can decrease the tumor volume and even disappeared and improved the rate of resection. And indication of operation was extended. Neoadjuvant radiotherapy didn't increase the surgical difficulties and complications. Compare of radical hysterectomy, Neoadjuvant radiotherapy can reduce the short-term radiation side effects and long-term complications. Neoadjuvant radiotherapy can depressed the viability of the cancer cells and reduced the chance of neoplasm metastasis. Compare of radical hysterectomy, Neoadjuvant radiotherapy can get similar or more higher the long-term survival. (authors)