Preparation and radiolabeling of antimony sulfide nanocolloids with two different particle sizes

Antimony sulfide nanocolloids with two different particle sizes were prepared by a modified traditional method and a new method. Transmission electron microscope (TEM) showed the mean particle sizes to be 10.2±2.3 and 44.7±13.8 nm, respectively. The nanocolloids were then radiolabeled with 99mTc, or with 188Re. The labeling yields of 99mTc-Sb2S3 (10.2±2.3 nm and 44.7±13.8 nm)>98% and >96% for 188Re-Sb2S3 (10.2±2.3 and 44.7±13.8 nm). The stability of the labeled products was studied at room temperature and all showed excellent stability except for 188Re-Sb2S3 (10.2±2.3 nm). The mechanism of labeling of nanocolloids with 188Re is different from that of 99mTc. The antimony sulfide nanocolloids prepared by the new method, after labeling are expected to have diagnostic or therapeutic potential in nuclear medicine