Use of radium-224 in the treatment of ankylosing spondylitis and rheumatoid synovitis
Creators
- 1. Centre Hospitalier Universitaire, 54 - Nancy (France)
Description
In Nancy, France, repeated injections of 224Ra have been given to adult patients since 1964 for the treatment of ankylosing spondylitis and rheumatoid synovitis of the knee. In the case of ankylosing spondylitis 60 patients have received 224Ra intravenously. The time from first to last injection varied from 2 months to 2 years. The total injected activity varied from 560 to 1680 μCi 224Ra. The treatment had a positive result for 65% of the patients. Rheumatoid joints in 80 patients were treated with intra-articularly injected 224Ra. Repeated injections were given during a period of several months. The total activity injected varied from 28 to 616 μCi 224Ra. Complete remission of joint symptoms was obtained in 35% of the cases. 224Ra has now been abandoned in favour of yttrium-90 or erbium-169 for the treatment of rheumatoid joints. A subsequent review of 104 of these 140 total patients has shown that no bone sarcomas or soft tissue cancers were observed after a period varying from 1 to 10 years after 224Ra injection. (author)
Additional details
Publishing Information
- Journal Title
- Health Phys.
- Journal Volume
- 35
- Journal Issue
- 1
- Journal Series
- Health Phys.
- Journal Page Range
- 57-60
- ISSN
- 0017-9078
Conference
- Title
- Biological effects of "2"2"4Ra and thorotrast. International symposium.
- Dates
- 21 - 23 Jul 1974.
- Place
- Alta, Utah, USA.
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United Kingdom
- INIS RN
- 10426652
- Subject category
- RADIATION PROTECTION AND DOSIMETRY; APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference
- Quality check status
- Yes
- Descriptors DEI
- BONE JOINTS; INJECTION; PATIENTS; RADIOTHERAPY; RADIUM 224; RHEUMATIC DISEASES; SPONDYLITIS;
- Descriptors DEC
- ALPHA DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; EVEN-EVEN NUCLEI; HEAVY NUCLEI; INTAKE; ISOTOPES; MEDICINE; NUCLEI; ORGANS; RADIOISOTOPES; RADIUM ISOTOPES; SKELETAL DISEASES; SKELETON; THERAPY;