Radioisotope method researches of pharmaceutical preparates

Full text: The development of modern stage of nuclear medicine is characterized by the increasing role of methods using radionuclides. Radioactive nuclides used in nuclear medicine may be divided into 2 groups. Radionuclides used for diagnostic researches and radionuclides used for therapeutic purposes. These two directions are considered to be the main ones in usage of radionuclides in medicine. However there is one more direction in the research of new medical products where it is possible to use radionuclides to study their pharmacological kinetics. In these researches radionuclide is applied as a radioactive label at the stage of studying pharmacological kinetics of a new medical product. In Institute of Nuclear Physics AS RU the works are being carried out in the recent years focused on studying pharmacology of some new medical preparations, which are synthesized in Tashkent Pharmaceutical Institute. Syntheses these preparations are based on use microelements. Its compounds are possessed expressed biological activity and be of great importance in the pharmaceutical science of Uzbekistan. Introducing a radioisotope at the stage of synthesis carried out reception of labeled connections of all preparations. The output of the final product reached the yield of no less than 80 percent in all cases of synthesis. This work presents the results of research on synthesis and study of pharmacology of radioactively labeled preparations - Piracin, labeled by radioisotope Zn69I; Cobavit, labeled by radioisotope Co 57; NI 101, labeled by radioisotope Co 57. Received radioisotope - labeled compounds of medical preparations were used in the study of their pharmacological kinetics. In all cases, preliminary irradiation of corresponding nuclear targets in the nuclear reactor and cyclotron, radiochemical procedures on separation, purification and concentration of radioactive isotopes, and reception of its radioactive solution for synthesis of labeled compounds of preparations were carried out. The received results allowed to reduce the terms of carrying out clinical tests of medical products considerably and to speed up their introduction in medical practice