Published November 1988 | Version v1
Journal article Metadata-only

Time dependence of chromosomal aberrations induced in human and monkey lymphocytes by acute and fractionated exposure to 60Co

Creators

  • 1. Commissariat a l'energie atomique, IPSN/DPS/SPE, Fontenay aux Roses (France)

Description

Changes in the numbers of peripheral lymphocytes with chromosome aberrations were observed in cynomolgus monkeys after fractionated or acute 60Co irradiation at the same total doses. Immediately after irradiation, the yield of dicentrics decreased when the dose was fractionated but remained constant for 20 to 80 days, depending on the dose, when irradiation was acute. Lymphopenia was greater than expected when the dose was fractionated. The kinetics of the loss of chromosome aberrations and the changes in peripheral lymphocyte count occurring in monkeys after acute irradiation were compared to those observed in accidentally irradiated men

Additional details

Publishing Information

Journal Title
Radiation Research
Journal Volume
116
Journal Issue
2
Series
Radiat. Res.
Journal Page Range
254-262
ISSN
0033-7587
CODEN
RAREA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
20025885
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ACUTE IRRADIATION; CHROMOSOMAL ABERRATIONS; COBALT 60; FRACTIONATED IRRADIATION; GENETIC RADIATION EFFECTS; IN VITRO; LYMPHOCYTES; MAN; MONKEYS; RADIATION DOSES; RADIATION EFFECTS; TIME DEPENDENCE; WHOLE-BODY IRRADIATION
Descriptors DEC
ACUTE EXPOSURE; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; EXTERNAL IRRADIATION; GENETIC EFFECTS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEUKOCYTES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; MUTATIONS; NUCLEI; ODD-ODD NUCLEI; PRIMATES; RADIOISOTOPES; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES